Sulfur-containing heterocyclic compounds with potential antidiabetic activity

E. A. Savateeva; V. V. Emelyanov; A. V. Musalnikova; L. P. Sidorova; N. E. Maksimova; N. N. Machulskaya; V. A. Chereshnev

doi:10.15826/chimtech.2014.1.3.1161

Sulfur-containing heterocyclic compounds with potential antidiabetic activity

E. A. Savateeva, V. V. Emelyanov, A. V. Musalnikova, L. P. Sidorova, N. E. Maksimova, N. N. Machulskaya, V. A. Chereshnev

Abstract

The essential link in the pathogenesis of diabetes mellitus and its complications is a non-enzymatic glycosylation of proteins. However, modern endocrinology lacks of clinically effective pharmaceuticals for its correction. The screening of 23 derivatives of 1,3,4-thiadiazine the ability to inhibit the reaction of non-enzymatic glycosylation of proteins in vitro was held, and 11 the most active compounds of them were selected, also the relationship «structure – activity» was investigated. An essential part of the pathogenesis of diabetes mellitus and its complications is non-enzymatic glycosylation of proteins. However, modern endocrinology lacks clinically effective medicines for its correction.

Keywords

1,3,4-Thiadiazine; antidiabetic activity; non-enzymatic glycosylation of proteins; screening; structure-activity

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References

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DOI: https://doi.org/10.15826/chimtech.2014.1.3.1161

Copyright (c) 2014 E. A. Savateeva, V. V. Emelyanov, A. V. Musalnikova, L. P. Sidorova, N. E. Maksimova, N. N. Machulskaya, V. A. Chereshnev

This work is licensed under a Creative Commons Attribution 4.0 International License.

Chimica Techno Acta, 2014–2025
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