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Sulfur-containing heterocyclic compounds with potential antidiabetic activity

E. A. Savateeva, V. V. Emelyanov, A. V. Musalnikova, L. P. Sidorova, N. E. Maksimova, N. N. Machulskaya, V. A. Chereshnev

Abstract


The essential link in the pathogenesis of diabetes mellitus and its complications is a non-enzymatic glycosylation of proteins. However, modern endocrinology lacks of clinically effective pharmaceuticals for its correction. The screening of 23 derivatives of 1,3,4-thiadiazine the ability to inhibit the reaction of non-enzymatic glycosylation of proteins in vitro was held, and 11 the most active compounds of them were selected, also the relationship «structure – activity» was investigated. An essential part of the pathogenesis of diabetes mellitus and its complications is non-enzymatic glycosylation of proteins. However, modern endocrinology lacks clinically effective medicines for its correction.

Keywords


1,3,4-Thiadiazine; antidiabetic activity; non-enzymatic glycosylation of proteins; screening; structure-activity

References


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Emeliyanov VV, Maksimova NE, Mochul’skaya NN, Chereshnev VA. [Nonenzymatic glycosylation of proteins: chemistry, pathophysiology, perspective correction]. Voprosy biologicheskoy, meditsinskoy i farmatsevticheskoy khimii [Problems of biological, medical and pharmaceutical chemistry]. 2010;1:3-15. Russian.




DOI: http://dx.doi.org/10.15826/chimtech.2014.1.3.1161

Copyright (c) 2014 E. A. Savateeva, V. V. Emelyanov, A. V. Musalnikova, L. P. Sidorova, N. E. Maksimova, N. N. Machulskaya, V. A. Chereshnev

© Chimica Techno Acta, 2014-2018
ISSN 2411-1414 (Online), ISSN 2409-5613 (Print)

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