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6-Aminotriazolo[1,5-a]pyrimidines as precursors of 1,2,4-triazolo[5,1-b]purines

K. V. Savateev, S. S. Borisov, E. K. Voinkov, E. N. Ulomsky, V. L. Rusinov, O. N. Chupakhin

Abstract


Triazolo[5,1-b]purines are rare structural analogues of natural nucleosides and nucleobases purine  series. At the same time, prominent representatives of azolopurines exhibit a broad spectrum of   antiviral effect, activity against of rheumatoid arthritis, psoriasis, Alzheimer's, Parkinson's and etc.  Despite the practical value azolo[5,1-b]purines extremely sparingly represented in the chemical literature, due to the complexity of their synthesis. We suggest a convenient way to synthesize   triazolopurines with aminotriazolo[1,5-a]pyrimidines (2) as available starting compounds obtained in good yield by reduction of nitro derivatives (1).

Keywords


6-Aminotriazolo[1,5-a]pyrimidines; 1,2,4-triazolo[5,1-b]purines; Alzheimer's; Parkinson's; reduction of nitrogroup

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References


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Zhao XL, Zhao YF, Guo SC, Song HS, Wang D, Gong P. Synthesis and Anti-tumor Activities of Novel [1,2,4]triazolo[1,5-a]pyrimidines. Molecules. 2007;12(5):1136-46. doi:10.3390/12051136




DOI: https://doi.org/10.15826/chimtech.2015.2.2.013

Copyright (c) 2015 K. V. Savateev, S. S. Borisov, E. K. Voinkov, E. N. Ulomsky, V. L. Rusinov, O. N. Chupakhin

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Chimica Techno Acta, 2014-2022
ISSN 2411-1414 (Online)