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The redox transformations and nucleophilic replacements as possible metabolic reactions of the drug “Triazaverin”. The chemical modeling of the metabolic processes

N. R. Medvedeva, I. S. Sapozhnikova, V. L. Rusinov, E. N. Ulomsky


As a model of metabolic transformations of antiviral drug “Triazaverin” and its analogues‑2-alkylthio‑6-nitro‑1,2,4-triazolo[5,1-c][1,2,4]triazine‑7-ones 1a-d examined the oxidation of alkylthio groups to the corresponding sulfoxides 2a-d and sulfones 3a-d, as well as the process of nucleophilic substitution sulfonyloxy group of cysteine and cysteamine with the formation of compounds 5 and 6.


biological active compounds; heterocycles; triazine; Triazaverin; antiviral drug

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Copyright (c) 2015 N. R. Medvedeva, I. S. Sapozhnikova, V. L. Rusinov, E. N. Ulomsky

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Chimica Techno Acta, 2014-2023
ISSN 2411-1414 (Online)
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