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The redox transformations and nucleophilic replacements as possible metabolic reactions of the drug “Triazaverin”. The chemical modeling of the metabolic processes

N. R. Medvedeva, I. S. Sapozhnikova, V. L. Rusinov, E. N. Ulomsky

Abstract


As a model of metabolic transformations of antiviral drug “Triazaverin” and its analogues‑2-alkylthio‑6-nitro‑1,2,4-triazolo[5,1-c][1,2,4]triazine‑7-ones 1a-d examined the oxidation of alkylthio groups to the corresponding sulfoxides 2a-d and sulfones 3a-d, as well as the process of nucleophilic substitution sulfonyloxy group of cysteine and cysteamine with the formation of compounds 5 and 6.

Keywords


biological active compounds; heterocycles; triazine; Triazaverin; antiviral drug

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References


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DOI: http://dx.doi.org/10.15826/chimtech.2015.2.3.025

Copyright (c) 2015 N. R. Medvedeva, I. S. Sapozhnikova, V. L. Rusinov, E. N. Ulomsky

© Chimica Techno Acta, 2014-2019
ISSN 2411-1414 (Online), ISSN 2409-5613 (Print)

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