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Combinatorial approach to the synthesis of substituted 1,2,4-triazines

D. N. Kozhevnikov, V. N. Kozhevnikov


This article describes a convenient and easy method of substitution of the
nitrile group in 5-cyano-1,2,4-triazines with the aim of obtaining of libraries of
substituted 1,2,4-triazines (about 500 compounds).


nucleophiles; nitrile group; 1,2,4-triazines

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Huang JJ. Synthesis of fused 1,2,4-triazines: 6- and 7-azapteridine and 6-azapurine ring systems. J Org Chem. 1985;50(13):2293–8. doi:10.1021/jo00213a019

Rykowski A, Branowska D, Makosza M, Ly VP. Reactions of 1,2,4-triazines with nitromethide ion. A convenient method of preparation of 1,2,4-triazin-5-ylcarbaldehyde oximes and their synthetic applications. J Heterocycl Chem. 1996;33(6):1567–71. doi:10.1002/jhet.5570330603

Kozhevnikov VN, Kozhevnikov DN, Shabunina OV, Kataeva NN, Yushchuk SA, Rusinov VL, Chupakhin ON. From 3-chloromethyl-1,2,4-triazine 4-oxides to various substituted pyridines and 1,2,4-triazines. Russ Chem Bull. 2005;54(9):2187–96. doi:10.1007/s11172-006-0095-4

Kozhevnikov DN, Kozhevnikov VN, Kovalev IS, Rusinov VL, Chupakhin ON, Aleksandrov GG. Transformations of 1,2,4-Triazines in Reactions with Nucleophiles: V. SNH and ipso-Substitution in the Synthesis and Transformations of 5-Cyano-1,2,4-triazines. Russ J Org Chem. 2002;38(5):744–50. doi:10.1023/A:1019631610505

Prokhorov AM, Kozhevnikov DN, Rusinov VL, Matern AI, Nikitin MM, Chupakhin ON, Eremenko IL, Aleksandrov GG. 5-Acylmethyl-3-(2-pyridyl)-1,2,4-triazines: Synthesis and Complexes with Cu(II). Russ J Org Chem. 2005;41(11):1702–5. doi:10.1007/s11178-006-0022-z

Kopchuk DS, Chepchugov NV, Kovalev IS, Santra S, Rahman M, Giri K, Zyryanov GV, Majee A, Charushin VN, Chupakhin ON. Solvent-free synthesis of 5-(aryl/alkyl)amino-1,2,4-triazines and α-arylamino-2,2′-bipyridines with greener prospects. RSC Adv. 2017;7:9610–19. doi:10.1039/C6RA26305D


Copyright (c) 2017 D. N. Коzshevnikov, V. N. Коzshevnikov

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Chimica Techno Acta, 2014-2024
ISSN 2411-1414 (Online)
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