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Two mutually complementary synthetic approaches towards 3-substituted 3,4-disubstituted and 1-(2-pyridyl)-substituted isoquinolines
Abstract
Two mutually complementary synthetic approaches towards 3- and 3,4-disubstituted 1-(2-pyridyl) isoquinolines were studied. The aryne-based method was successfully used for the obtaining of the corresponding the 3-cyano-1-(2-pyridyl)isoquinolines in one step/pot reaction, while it is unacceptable for the obtaining of other 1-(2-pyridyl)isoquinolines. The enamine-based approach was successfully applied for the synthesis of other 1-(2-pyridyl)isoquinolines, while it was unacceptable for the obtaining of 3-cyano-1-(2-pyridyl)isoquinolines.
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DOI: https://doi.org/10.15826/chimtech.2018.5.3.04
Copyright (c) 2018 I.L. Nikonov, D.S. Kopchuk, A.F. Khasanov, A.P. Krinochkin, E. S. Starnovskaya, Ya. K. Shtaiz, M.I Savchuk, O.S. Tanya, G.V. Zyryanov, V.L. Rusinov, O.N. Chupakhin
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