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Technology for the industrial production of K3 series vitamins based on menadione

Aleksey S. Antipov, Vasily A. Nizov, Anna Yu. Antipova

Abstract


An improved technology for the industrial production of K3 series vitamins based on menadion is reported. The procedure involves the Cr(VI)-promoted oxidation of the corresponding methyl-naphtahelenes with the following purification by precipitation/recrystallization. The best results were obtained under the process temperature between 20-40 °C, solution pH after dilution of MNB in a range of 5.5–5.7, and MNB content in initial solution of 25-30%.

Keywords


Vitamin K3; methyl-naphalenes; Cr(VI)-compounds; menadione; industrial scale

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References


Weber F, Rüttimann A. Vitamin K. Ullmann's Encyclopedia of Industrial Chemistry. Weinheim: Wiley-VCH, 2012. 38. pp. 211-31.

Scott GK, Atsriku C, Kaminker P, Held J, Gibson B, Baldwin MA, Benz CC. Vitamin K3 (menadione)-induced oncosis associated with keratin 8 phosphorylation and histone H3 arylation. Molecular Pharmacology. 2005;68:606-15.

Belikov VG. Farmatsevticheskaya khimiya. Chast' 2. Spetsial'naya farmatsevticheskaya khimiya. Pyatigorsk. 1996. pp. 152-5. Russian.

Antipov AS, Nizov VA. Sintez menadiona (2-metil-1,-naftokhinona) s ispol'zovaniyem soyedineniy Cr6+. Bashkirskiy khimicheskiy zhurnal. 2019;26(2):100-5. Russian.

Antipov AS, Nizov VA. Analiz vozmozhnostey polucheniya menadiona s naimen'shim soderzhaniyem primesey khroma. Bashkirskiy khimicheskiy zhurnal. 2018;25(1):27-32. Russian.

Stepin BD, Gorshteyn IG, Blyum GZ, Kurdyumov GM, Ogloblina IP. Metody polucheniya osobo chistykh neorganicheskikh veshchestv. Leningrad: Khimiya; 1969. 480 p. Russian.

Antipov AS, Nizov VA. Fraktsionirovaniye khroma v protsesse izogidricheskoy kristallizatsii menadiona natriya bisul'fita (2-metil-1,4-diokso-1,2,3,4-tetragidro-2-naftalinsul'fonat natriya). Bashkirskiy khimicheskiy zhurnal. 2018:25(4):11-5. Russian.

Antipov AS, Nizov VA, Gvozdev AV, Antipova AYu, inventors; Federal Institute of the Industrial Property, assignee. Sposob polucheniya vitaminov serii K3. Russian Federation patent RU 2696493. 2018. Russian.

Antipov AS, Nizov VA, Gvozdev AV, Antipova AYu, inventors; Federal Institute of the Industrial Property, assignee. Sposob polucheniya vitaminov serii K3. Russian Federation patent RU 2696776. 2018. Russian.

Bicker M, Bierstedt A, Amouzegar K, Mahdavi B, Stamant G, assignee. Recovery of vitamin K3 from mother liquor. European patent WO2010121638. 2010.




DOI: https://doi.org/10.15826/chimtech.2020.7.2.05

Copyright (c) 2020 Aleksey S. Antipov, Vasily A. Nizov, Anna Yu. Antipova

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Chimica Techno Acta, 2014-2024
ISSN 2411-1414 (Online)
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