Graphical Abstract

8-Hydroxy-5-nitroquinoline as a C-nucleophilic reagent in the reaction of C, C-coupling with quinazoline

Yuri A. Azev, Olga S. Koptyaeva, Oleg S. Eltsov, Anton N. Tsmokalyuk, Tatyana A. Pospelova

Abstract


The first example of the reaction of 5-nitro-8-hydroxyquinoline as a C-nucleophile with quinazoline is described. As a result of the reaction of C, C-coupling, a stable σ-adduct containing the drug nitroxalin on a heterocyclic carrier was obtained. The structure of the resulting adduct was confirmed by 2D 1H-13C HSQC, 1H-13C HMBC, and 1H-15N HMBC spectra.

Keywords


5-nitro-8-hydroxyquinoline; quinazoline; C, C-coupling

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References


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DOI: https://doi.org/10.15826/chimtech.2020.7.4.18

Copyright (c) 2020 Yuri Azev, Olga Koptyaeva, Oleg Eltsov, Anton Tsmokalyuk, Tatyana Pospelova

© Chimica Techno Acta, 2014-2020
ISSN 2411-1414 (Online), ISSN 2409-5613 (Print)

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