Graphical Abstract

Direct CH/CH functionalization of 1,3-dihydroxy-9H-xanthen-9-one and 1,3-dimethoxy-9H-xanthen-9-one with 1,2,4-triazines and quinazoline

A. D. Sharapov, R. F. Fatykhov, I. A. Khalymbadzha, O. N. Chupakhin

Abstract


An electron-deficient series of 1,2,4-triazines and quinazoline have been used for cross-dehydrogenative coupling with 1,3-dihydroxy and 1,3-dimethoxyxanthones to give stable nucleophilic addition products. The adducts and their subsequent oxidation products were obtained in good yields and the structures of the compounds were confirmed by 1H NMR spectroscopy. These results expand the scope of the methodology of nucleophilic substitution of hydrogen with the participation of xanthones with azines. Moreover, this methodology makes it possible to obtain new organic materials based on xanthones, which have a wide spectrum of biological activity.


Keywords


сross-dehydrogenative coupling reactions; 1,2,4-triazines; quinazolines; xanthones

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References


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DOI: https://doi.org/10.15826/chimtech.2020.7.4.17

Copyright (c) 2020 A. D. Sharapov, R. F. Fatykhov, I. A. Khalymbadzha, O. N. Chupakhin

© Chimica Techno Acta, 2014-2020
ISSN 2411-1414 (Online), ISSN 2409-5613 (Print)

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