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Detection of Anti-viral Drug Riamilovir and Herbicides in Aqueous Media by Using Pyrene-based Fluorescent Chemosensors

I. S. Kovalev, L. K. Sadieva, O. S. Taniya, D. S. Kopchuk, G. V. Zyryanov, E. N. Ulomsky, V. L. Rusinov, O. N. Chupakhin

Abstract


Two ethyleneglycol esters of 1-pyrene carboxylic acid were studied as chemosensors for the fluorescence “turn-off” detection of two nitro-containing analytes, such as antiviral drug Riamilovir (Triazavirin ®) and herbicidal agent dinitro-ortho-cresol (DNOC). In both cases the dramatic fluorescence quenching was observed with quenching constants as high as 3·104 M-1 and limits of detection (LOD) as low as 100 ppb.

Keywords


COVID-19; Riamilovir (Triazavirin ®); DNOC; detection in aqueous media; chemical sensors; pyrene-based fluorophores; fluorescence quenching

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References


Wu X, Yu K, Wang Y, Xu W, Ma H, Hou Y, et al. Efficacy and Safety of Triazavirin Therapy for Coronavirus Disease 2019: A Pilot Randomized Controlled Trial. Engineering. 2020;6(10):1185–91. doi:10.1016/j.eng.2020.08.011

Sabitov AU, Belousov VV, Edin AS, Oleinichenko EV, Gladunova EP, Tikhonova EP, et al. Practical experience of using riamilovir in treatment of patients with moderate COVID-19. Antibiotiki i Khimioterapiya. 2020;65(7–8):27–30. Russian. doi:10.37489/0235-2990-2020-65-7-8-27-30

Ayoob AM, Peppi M, Tandon V, Langer R, Borenstein JT. A fluorescence-based imaging approach to pharmacokinetic analysis of intracochlear drug delivery. Hear Res. 2018;368:41–8. doi:10.1016/j.heares.2018.03.026

Kuneš M, Květina J, Maláková J, Bureš J, Kopáčová M, Rejchrt S. Pharmacokinetics and organ distribution of fluorescein in experimental pigs: An input study for confocal laser endomicroscopy of the gastrointestinal tract. Neuroendocrinol Lett [Internet]. 2010;31(Suppl. 2):57–61. Available from: https://www.nel.edu/userfiles/articlesnew/NEL31S210A09.pdf

Lyle K. Environmental Health Criteria 220 DINITRO-ortho-CRESOL [Internet]. 2000. Available from: https://www.who.int/ipcs/publications/ehc/en/ehc220.pdf

Toxicological Profile for Dinitrocresols. ATSDR’s Toxicological Profiles [Internet]. 2018. Available from: https://www.atsdr.cdc.gov/toxprofiles/tp63.pdf

Sadieva LK, Taniya OS, Kovalev IS, Kopchuk DS, Zyryanov GV, Rusinov VL, et al. Polietilenglikolevyye efiry piren-1-karbonovoy kisloty: sintez i fotofizicheskiye issledovaniya [Polyethylene glycol esters of 1-Pyrenecarboxylic acid: synthesis and photophysical studies]. Izv Acad Nauk. 2021;4. Forthcoming 2021.

DAS-6 Operation Manual [Internet]. Horiba Scientific; 117 p. Available from: https://www.horiba.com/fileadmin/uploads/Scientific/Downloads/UserArea/Fluorescence/Manuals/DAS67_Manual.pdf

Shrivastava A, Gupta V. Methods for the determination of limit of detection and limit of quantitation of the analytical methods. Chronicles Young Sci. 2011;2(1):21. doi:10.4103/2229-5186.79345




DOI: https://doi.org/10.15826/chimtech.2021.8.2.08

Copyright (c) 2021 I.S. Kovalev, L.K. Sadieva, O.S. Taniya, D.S. Kopchuk, G.V. Zyryanov, E.N. Ulomsky, V.L. Rusinov, O.N. Chupakhin

© Chimica Techno Acta, 2014-2021
ISSN 2411-1414 (Online)

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