New molecular complex of ammonium glycyrrhizate with rutin

L. A. Yakovishin; V. D. Ratnikov; P. I. Bazhan; G. P. Zaitsev

doi:10.15826/chimtech.2022.9.1.01

New molecular complex of ammonium glycyrrhizate with rutin

L. A. Yakovishin, V. D. Ratnikov, P. I. Bazhan, G. P. Zaitsev

Abstract

A new 1:1 molecular complex of triterpene glycoside ammonium glycyrrhizate (GC) with flavonoid glycoside rutin (Rut) was obtained in aqueous ethanol. The stability constant (9.7±0.2)×10⁴ (mol/L)^–1 was calculated for the complex via isomolar curves. The complexation was studied by UV- and ATR IR-Fourier spectroscopy and a method of isomolar series. The hydrogen bonds and hydrophobic interactions are formed in the molecular complex. A preliminary antioxidant activity assessment of the complex was made.

Keywords

triterpene glycosides; ammonium glycyrrhizate; rutin; molecular complex; antioxidant capacity

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References

Gullón B, Lú-Chau TA, Moreira MT, Lema JM, Eibes G. Ru-tin: a review on extraction, identification and purification methods, biological activities and approaches to enhance its bioavailability. Trends Food Sci Technol. 2017;67:220–35. doi:10.1016/j.tifs.2017.07.008

Yakovishin LA, Grishkovets VI. Ivy and licorice triterpene glycosides: promising molecular containers for some drugs and biomolecules. Stud Nat Prod Chem. 2018;55:351–83. doi:10.1016/B978-0-444-64068-0.00011-5

Khizrieva SS, Vetrova EV, Borisenko SN, Maksimenko EV, Borisenko NI. Synthesis and study of complexes of the novel russian antiviral drug camphecene with pentacyclic triter-penes of licorice. Chimica Techno Acta. 2020;7(4):192–98. doi:10.15826/chimtech.2020.7.4.10

Yakovishin LA, Grishkovets VI. Intermolecular interaction of glycyrrhizin with cholesterol. Chimica Techno Acta. 2020;7(4)180–85. doi:10.15826/chimtech.2020.7.4.08

Yakovishin LA. Molecular complex of glycyrrhizic acid mon-oammonium salt with cholesterol. Curr Bioact Compd. 2020;16(7)1042–48. doi:10.2174/1573407215666191007111603

Yakovishin LA, Korzh EN. Molecular complex of quercetin with glycyram. AIP Conference Proceedings. 2019;2063:040066. doi:10.1063/5.0018047

Yakovishin LA, Grishkovets VI, Korzh EN, Golovchenko IV, Nagirnyak AA. Molecular complexation of hederasaponin C with cholesterol in aqueous isopropyl alcohol. Chimica Techno Acta. 2020;7(4):150–53. doi:10.15826/chimtech.2020.7.4.02

Myshkin VA, Srubilin DV, Enikeev DA. Antioxidant proper-ties of pyrimidine derivatives and their molecular complex-es with biologically active substances in various oxidative systems. Bashkortostan Med J. 2009;4(2):151–54. Russian.

Ragino YI, Vavilin VA, Salakhutdinov NF, Makarova SI, Sta-khneva EM, Safronova OG, Lyakhovich VV, Nikitin YuP, Tolstikov GA. Antioxidant and endothelium-stabilizing ef-fects of simvaglyzin on rabbits with experimental hypercho-lesterolemia. Bull Exp Biol Med. 2008;146(2):206–209. doi:10.1007/s10517-008-0252-x

DOI: https://doi.org/10.15826/chimtech.2022.9.1.01

Copyright (c) 2021 L.A. Yakovishin, V.D. Ratnikov, P.I. Bazhan, G.P. Zaitsev

This work is licensed under a Creative Commons Attribution 4.0 International License.

Chimica Techno Acta, 2014-2024
ISSN 2411-1414 (Online)
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