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On the possibility of obtaining the elastic and biocompatible film materials based on chitosan and N-succinyl chitosan
Abstract
For the first time, the studies of polyhydric alcohols (glycerol, ethylene glycol and propylene glycol) impact on the structure, deformation–strength characteristics and hemocompatibility of the film materials based on chitosan and N-succinyl chitosan were carried out. It was shown that the introduction of polyhydric alcohols into molding solutions during the creation of the films based on chitosan and succinyl chitosan in the amount up to 0.05 mol/l is accompanied by the tensile elongation value increase by 2–2.5 times. The value of the breaking stress in this case decreases by 3–4 times. There is also a decrease in the overall surface roughness and a sharp drop in the elastic modulus of the films. The stabilizing impact of the systems based on chitosan and succinyl chitosan in the presence of glycerol and propylene glycol upon the cell membranes in physiological conditions allows inferring their high hemocompatibility.
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Vinnik YUS, Markelova NM, Solov'yeva NS, Shishatskaya YeI, Kuznetsov MN, Zuyev AP. Sovremennyye ranevyye pokrytiya v lechenii gnoynykh ran [Modern wound coat-ings in the treatment of purulent wans]. Novosti khirurgii. 2015;23(5):552–558. doi:10.18484/2305-0047.2015.5.552
Slivkin AI, Lapenko VL, Arzamastsev AP, Bolgov AA. Amino-glyukany v kachestve biologicheski aktivnykh kompo-nentov lekarstvennykh sredstv (obzor za period 2000–2004). Vestnik Voronezhskogo gosudarstvennogo universi-teta. Seriya: Khimiya. Biologiya. Farmatsiya. 2005;(2):73–87.
Alekseeva TP, Bogoslovskaya OA, Olkhovskaya IP, Glush-chenko NN, Rakhmetova AA, Ilina AV, Varlamov VP, Baitukalov TA, Levov AN. Wound healing potential of chi-tosan and N-sulfosuccinoyl chitosan derivatives. Biol Bul. 2010;37(4):339–345. doi:10.1134/S1062359010040023
Buzinova DA, Abramov AYU, Shipovskaya AB. Svoystva ple-nok iz khitozana raznykh khimicheskikh form [Properties of films made of chitosan of different chemical forms]. Izv Sarat University. Nov Ser Khimiya Biologiya Ekologiya. 2011;11(2):31–38.
Bazunova MV, Sharafutdinova LA, Lazdin RY, Chernova VV, Mixonov DN, Zakharov VP. Мaterials based on chitosan suc-cinamide–glycerol systems. Appl Biochem Microbiol. 2018;54(5):474–477. doi:10.1134/S0003683818050058
Hirase R, Higashiyama Y, Mori M, Takahara Y, Yamane C. Hydrated salts as both solvent and plasticizer for chitosan. Carbohydr Polym. 2010;80(3):993–996.
Fedoseyeva YeN, Alekseyeva MF, Smirnova LA. Мekhanich-eskiye svoystva plenok khitozana razlichnoy mole-kulyarnoy massy [Мechanical properties of chitosan films of different molecular mass]. Vestnik Nizhegorodskogo universiteta im. N.I. Lobachevskogo. 2008;5:58–62.
Shurshina AS, Bazunova MV, Chernova VV, Galina AR, Lazdin RY, Kulish EI. Influence of supramolecular organi-zation on some characteristics of chitosan succinamide films produced from aqueous solutions. Polym Sci Ser A. 2020;62(4):422–429. doi:10.1134/S0965545X20040100
Rogovina SZ, Akopova TA, Zelenetskii AN, Vikhoreva GA, Gorbacheva IN, Zharov AA. А study of cellulose-chitosan blends obtained under shear strain. Polym Sci Ser A. 2000;42(1):5–9.
Komarov BA, Albulov AI, Belov MYu, Samuylenko AYa, Fo-menko AS, Shinkarev SM, Trunov AM. Method for produc-ing sodium salt of chitosan succinate. Russian Federation patent RU 2144040. 1998 Apr 07. Russian.
Zhou Y, Li J, Lu F, Deng J, Zhang J, Fang P, et. al. A study on the hemocompatibility of dendronized chitosan derivatives in red blood cells. Drug Design Develop Therapy. 2015;9:2635–2645. doi:10.2147/DDDT. S77105
Lazdin RY, Chernova VV, Bazunova MV, Zakharov VP. Rheo-logical properties of chitosan succinimide in water-glycerol mixed solvent. Russ J Appl Chem. 2019;92(1):50–56. doi:10.1134/S1070427219010075
Bazunova MV, Chernova VV, Lazdin RY, Zakharov VP, Kulish EI. A study of the viscosity characteristics of chitosan solu-tions in the presence of organic cosolvents. Russ J Phys Chem B. 2018;12(6):1039–1044. doi:10.1134/S1990793118060143
Tager AA. Fiziko-khimiya polimerov [Physicochemistry of polymers]. Moscow: Nauchnyy mir; 2007. 574 p. Russian.
DOI: https://doi.org/10.15826/chimtech.2022.9.1.08
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