Improved method for the obtaining DTTA-appended 2,2’-bipyridine ligands for lanthanide cations

Dmitry S. Kopchuk; Alexey P. Krinochkin; Мaria I. Valieva; Еkaterina S. Starnovskaya; Yaroslav K. Shtaitz; Svetlana S. Rybakova; Evgeny D. Ladin; Ekaterina A. Kudryashova; Elvira R. Sharafieva; Оleg N. Chupakhin

doi:10.15826/chimtech.2022.9.2.10

Improved method for the obtaining DTTA-appended 2,2’-bipyridine ligands for lanthanide cations

Dmitry S. Kopchuk, Alexey P. Krinochkin, Мaria I. Valieva, Еkaterina S. Starnovskaya, Yaroslav K. Shtaitz, Svetlana S. Rybakova, Evgeny D. Ladin, Ekaterina A. Kudryashova, Elvira R. Sharafieva, Оleg N. Chupakhin

Abstract

The composition of the reaction mixture after DTTA tert-butyl ester alkylation with 6'-halomethyl-5-phenyl-2,2'-bipyridines was studied. In addition to the target product, DTTA-appended 2,2’-bipyridine, the corresponding 6'-hydroxymethyl-substituted 2,2’-bipyridine and (5'-phenyl-[2,2'-bipyridin]-6-yl)methyl formate were isolated as by-products in some cases. Finally, an improved procedure for the DTTA tert-butyl ester alkylation with 6'-halomethyl-5-phenyl-2,2'-bipyridines by using Finkelstein reaction was developed.

Keywords

DTTA tert-butyl ester; 2,2'-bipyridines; Finkelstein reaction; ligands for lanthanide cations; alkylation

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DOI: https://doi.org/10.15826/chimtech.2022.9.2.10

Copyright (c) 2022 Dmitry S. Kopchuk, Alexey P. Krinochkin, Мaria I. Valieva, Еkaterina S. Starnovskaya, Yaroslav K. Shtaitz, Svetlana S. Rybakova, Evgeny D. Ladin, Ekaterina A. Kudryashova, Elvira R. Sharafieva, Оleg N. Chupakhin

This work is licensed under a Creative Commons Attribution 4.0 International License.

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