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PEG- 4000 increases solubility and dissolution rate of vinpocetin in solid dispersion system

Yulia A. Polkovnikova, Tamara N. Glizhova, Naira V. Arutyunova, Natalya N. Sokulskaya


In the present work investigations were performed concerned with the determination of the optimal ratio of vinpocetine and polyethylene glycol within a solid dispersion (1:2 or 1:5) according to the simulation results in the framework of molecular dynamics associated with the release of the reactant into aqueous medium. For the simulation of vinpocetine release from its alloy with polyethylene glycol a technique of coarse-grained molecular dynamics in the force field of Martini 2.2 was applied with the use of Gromacs 2018 computer program. Results of the simulation demonstrated that at pH 6.8 polyethylene glycol facilitated vinpocetine solubilization and thus considerably enhanced its solubility in water. The data obtained show that the values of the energies of van der Waals interaction between vinpocetine and the polymer, as well as vinpocetine and water, both at a ratio of 1:2 and at a ratio of 1:5 are similar.


vinpocetin; solid dispersion system; PEG-4000; dissolution rate

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Golob S, Perry M, Lusi M, Chierotti MR, Grabnar I, Lassiani L, Voinovich D, Zaworotko MJ. Improving biopharmaceutical properties of vinpocetine through cocrystallization. J Pharm Sci. 2016;105(12):3626–3633. doi:10.1016/j.xphs.2016.09.017

Verma S, Rudraraju VS. A systematic approach to design and prepare solid dispersions of poorly water-soluble drug. AAPS Pharm Sci Tech. 2014;15(3):641–657. doi:10.1208/s12249-014-0093-z

Allawadi D, Singh N, Singh S, Arora S. Solid dispersions: a review on drug delivery system and solubility enhance-ment. Int J Pharm Sci Res. 2013;4(6);2094–2105. doi:10.13040/IJPSR.0975-8232.4(6).2094-05

Patil RM, Maniyar AH, Kale MT, Akarte AP, Baviskar DT. Solid dispersion: strategy to enhance solubility. Int J Pharm Sci Rev Res. 2011;8(2):66–73. doi:10.1007/s10973-016-5759-1

Di L, Fish PV, Mano T. Bridging solubility between drug discovery and development. Drug Discov Today. 2012;17(9–10):486–495. doi:10.1016/j.drudis.2011.11.007

Good DJ, Rodríguez-Hornedo N. Solubility Advantage of Pharmaceutical Cocrystals. Crys Growth Des. 2009;9(5):2252–2264. doi:10.1021/cg801039j

Brough C, Williams III RO. Amorphous solid dispersions and nano-crystal technologies for poorly water-soluble drug de-livery. Int J Pharm. 2013;453(1):157–166. doi:10.1016/j.ijpharm.2013.05.061

Chiou WL, Riegelman S. Pharmaceutical applications of solid dispersion systems. J Pharm Sci. 1971;60:1281–1302. doi:10.1002/jps.2600600902

Akiladevi D, Shanmugapandian P, Jebasingh D, Sachinandan B. Preparation and evaluation of Paracetamol by solid dis-persion technique. Int J Pharm. 2011; 3(11): 88–191. doi:10.13040/IJPSR.0975-8232.5(10).4478-8

Dubey A, Kharia AA, Chatterjee DP. Enhancement of aque-ous solubility and dissolution of telmisartan using solid dispersion technique. IJPSR. 2014;5(10):4478–4485. doi:10.13040/IJPSR.0975-8232.5(10).4478-85

Biswal S, Sahoo J, Murthy PN, Giradkar RP. Enhancement of dissolution rate of gliclazide using solid dispersions with polyethylene glycol 6000. AAPS Pharm Sci Tech. 2008;9(2):563–570. doi:10.1208/s12249-008-9079-z

Sharma A, Jain CP. Preparation and characterization of solid dispersions of carvedilol with PVP K30. Res Pharm Sci. 2010;5(1):49–56. doi:10.1007/s40005-013-0058-3

Setyawan D, Setiawardani F, Amrullah Z, Sari R. PEG 8000 increases solubility and dissolution rate of quercetin in sol-id dispersion system. Marmara Pharm J. 2018;22(2):445–456. doi:10.12991/mpj.2018.63

Arroyo ST, Sansón Martín JA, Hidalgo García A. Molecular dynamics simulation of acetamide solvation using interac-tion energy components: Application to structural and ener-gy properties. Chem Phys. 2006;327(1):187-192. doi:10.1016/j.chemphys.2006.04.018

Marrink SJ, Risselada HJ, Yefimov S, Tieleman DP, de Vries AH. The MARTINI force field: Coarse grained model for bio-molecular simulations. J Phys Chem B. 2007;111(27):7812–7824. doi:10.1021/jp071097f

Berendsen HJC, Postma JPM, Gunsteren WF, DiNola A, Haak JR. Molecular dynamics with coupling to an external bath. J Chem Phys. 1984;81(8):3684–3690. doi:10.1063/1.448118


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Chimica Techno Acta, 2014-2023
ISSN 2411-1414 (Online)
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