Synthesis of 5 H -Chromeno[4,3- b ]pyridin-5-one derivatives as a backbone of natural product polyneomarline C scaffolds in presence of Et 3 N and NH 4 OAc in EtOH

Shrishnu Kumar Kundu; Susanta Patra; Chayan Sardar; Sunil Kumar Bhanja; Prasanta Patra

doi:10.15826/chimtech.2022.9.2.11

Synthesis of 5H-Chromeno[4,3-b]pyridin-5-one derivatives as a backbone of natural product polyneomarline C scaffolds in presence of Et₃N and NH₄OAc in EtOH

Shrishnu Kumar Kundu, Susanta Patra, Chayan Sardar, Sunil Kumar Bhanja, Prasanta Patra

Abstract

A green one-pot synthesis of 5H-Chromeno[4,3-b]pyridin-5-one derivatives which are the main core of the natural product of Polyneomarline C is described by the reaction of 4-chloro-3-formyl coumarin and different cyclic and acyclic compounds having active methylene group in presence of Et₃N and NH₄OAc in EtOH. The advantages of this strategy are good yields, no need for the chromatographic separation and the absence of heavy metal catalysts and toxic by-products. The 4-chloro-3-formyl coumarin is obtained by Vilsmeier Heck reaction of 4-hydroxy coumarin.

Keywords

5H-Chromeno[4,3-b]pyridin-5-one; green synthesis; 4-chloro-3-formyl coumarin; active methylene group; Polyalthia nemoralis C

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References

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DOI: https://doi.org/10.15826/chimtech.2022.9.2.11

Copyright (c) 2022 Shrishnu Kumar Kundu, Susanta Patra, Chayan Sardar, Sunil Kumar Bhanja, Prasanta Patra

This work is licensed under a Creative Commons Attribution 4.0 International License.

Chimica Techno Acta, 2014-2024
ISSN 2411-1414 (Online)
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