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Substituted benzocoumarin derivatives: synthesis, characterization, biological activities and molecular docking with ADME studies

Megha G.V., Yadav D. Bodke, Shanavaz H., Muthipeedika Nibin Joy

Abstract


Herein, an efficient and convenient method for the synthesis of 4-(substitutedphenyl)-1,2-dihydro-2-oxo-6-(2-oxo-2H-benzo[g]chromen-3-yl)pyridine-3-carbonitrile derivatives have been reported using ammonium acetate as catalyst. The structures of synthesized compounds were confirmed using FT-IR, 1H, 13C-NMR and LC-MS spectroscopic techniques. The synthesized compounds have been evaluated for antibacterial activity against bacterial strains by agar diffusion method at different concentrations. Further, all the targeted compounds were screened for anti-oxidant and anti-cancer studies by DPPH and MTT assay methods at different concentrations. Compound 4b displayed good antioxidant and anticancer (against MCF-7 cell line) activity. Further, the binding capability for the synthesized compounds (4a–j) was analyzed by molecular docking studies using human peroxiredoxin 5 (PDB ID: 1HD2) and P38 MAP kinase (PDB ID: 1OUK) protein. Further, the physicochemical properties were analysed from ADME studies respectively.


Keywords


benzo-coumarin; anti-bacterial; anti-cancer; anti-oxidant; molecular docking

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References


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DOI: https://doi.org/10.15826/chimtech.2022.9.4.19

Copyright (c) 2022 Megha G.V., Yadav D. Bodke, Shanavaz H., Muthipeedika Nibin Joy

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Chimica Techno Acta, 2014-2022
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