Synthesis, intramolecular cyclization and anti-inflammatory activity of substituted 2-(2-(Furan-2-carbonyl)hydrazono)-4-oxobutanoic Acids

Sergei N. Igidov; Dmitriy V. Lipin; Aleksey Yu. Turyshev; Svetlana V. Chashchina; Daria A. Shipilovskikh; Ol’ga V. Zvereva; Ksenia A. Mitusova; Pavel S. Silaichev; Nazim M. Igidov

doi:10.15826/chimtech.2023.10.1.02

Synthesis, intramolecular cyclization and anti-inflammatory activity of substituted 2-(2-(Furan-2-carbonyl)hydrazono)-4-oxobutanoic Acids

Sergei N. Igidov, Dmitriy V. Lipin, Aleksey Yu. Turyshev, Svetlana V. Chashchina, Daria A. Shipilovskikh, Ol’ga V. Zvereva, Ksenia A. Mitusova, Pavel S. Silaichev, Nazim M. Igidov

Abstract

A method was proposed for the synthesis of substituted 2-(2-(furan-2-carbonyl)hydrazono)-4-oxobutanoic acids by the reaction of substituted 2,4-dioxobut-2-enoic acids with furan-2-carbohydrazide. It was found that substituted 2-(2-(furan-2-carbonyl)hydrazono)-4-oxobutanoic acids undergo intramolecular cyclization in the presence of propionic anhydride to form the corresponding N'-(2-oxofuran-3(2H)-ylidene)furan-2-carbohydrazides. The anti-inflammatory activity of the obtained compounds was studied. It was found that the obtained compounds have pronounced anti-inflammatory activity.

Keywords

dioxobutanoic acids; 2-hydrazono-4-oxobutanoic acids; 3-hydrazonofuran-2(3H)-ones; anti-inflammatory activity; drugs

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DOI: https://doi.org/10.15826/chimtech.2023.10.1.02

Copyright (c) 2022 Sergei N. Igidov, Dmitriy V. Lipin, Aleksey Yu. Turyshev, Svetlana V. Chashchina, Daria A. Shipilovskikh, Ol’ga V. Zvereva, Ksenia A. Mitusova, Pavel S. Silaichev, Nazim M. Igidov

This work is licensed under a Creative Commons Attribution 4.0 International License.

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