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2-(4-Oxo-1,3-thiazolidin-2-ylidene)acetamid as promising scaffold for designing new antifungal compounds
Abstract
1,3-Thiazolidin-4-one derivatives with a exocyclic C=C double bond in position 2 of the hetero ring have a wide spectrum of biological activity, but their fungicidal activity has not been studied as much as it should be. This paper presents a simple and convenient approach for obtaining potential antifungal agents based on 2-(4-oxo-1,3-thiazolidin-2-ylidene)acetamides. The first examples of evaluating the fungicidal activity of 8 obtained compounds on 8 strains of phytopathogenic fungi are presented. A highly active compound 4e with EC50 of 0.85 and 2.29 µg/mL against A. solani and P. lingam, respectively, was found to be promising for further study.
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DOI: https://doi.org/10.15826/chimtech.2023.10.1.06
Copyright (c) 2022 Konstantin L. Obydennov, Tatiana A. Kalinina, Daria V. Ryabova, Maria F. Kosterina, Tatiana V. Glukhareva
This work is licensed under a Creative Commons Attribution 4.0 International License.
Chimica Techno Acta, 2014-2024
ISSN 2411-1414 (Online)
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