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Synthesis and cytotoxic activity of (2-arylquinazolin-4-yl)hydrazones of 2-hydroxybenzaldehydes

Emiliya V. Nosova, Ilya I. Butorin, Margarita D. Likhacheva, Svetlana K. Kotovskaya

Abstract


2-Phenyl-6,7-difluoro and 2-(4-fluorophenyl)quinazoline derivatives bearing salicylidenhydrazino fragments at position 4 were prepared based on 4,5-difluoroantranilic acid or anthranilamide. Molecular docking to casein kinase 2 was performed; compounds with high in silico activity to CK2 were revealed. Cytotoxic activity of the synthesized compounds was studied on cancer cell line MDA-MB-231 and normal cell line WI26 VA4.

Keywords


2-arylquinazolines; salicylidenhydrazines; in silico activity; casein kinase 2 inhibitor; cytotoxic activity

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DOI: https://doi.org/10.15826/chimtech.2023.10.2.11

Copyright (c) 2023 Emiliya V. Nosova, Ilya I. Butorin, Margarita D. Likhacheva, Svetlana K. Kotovskaya

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