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Synthesis of 2-(5-arylidene-4-oxo-3-arylthiazolydine-2)-N-phenylethanthiamides derivatives from malondithioamides

K. L. Obydennov, N. A. Golovko, Yu. Yu. Morzherin


It is shown that thioacetamide are comfortable synthetic blocks for various heterocycles, including thiazole containing a double exocyclic bonds. This work describes the synthesis of (Z)-2-((Z)-5-arylidene-4-oxo-3-arylthiazolidin-2-ylidene)-N-arylethanethioamide 4 obtained from the Knoevenagel condensation of (Z)-2-(4-oxo-3-arylthiazolidin-2-ylidene)-N-arylylethanethioamide 2. The starting material 2 was synthesized by a Hantzsch reaction of N,N`-diarylmalondithioamides 1 and ethyl 2-chloroacetate. The structures of the obtained products were established by NMR and the structural features are discussed. Several 4-oxothiazolidin-2-ylidenes were studied by UV-visible spectroscopy technique


thiomalonamides; chromophores; Oxidation reaction; knoevenagel condensation; thiazole


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Copyright (c) 2014 K. L. Obydennov, N. A. Golovko, Yu. Yu. Morzherin

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Chimica Techno Acta, 2014-2023
ISSN 2411-1414 (Online)
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