Synthesis of 2-(5-arylidene-4-oxo-3-arylthiazolydine-2)-N-phenylethanthiamides derivatives from malondithioamides

K. L. Obydennov; N. A. Golovko; Yu. Yu. Morzherin

doi:10.15826/chimtech.2014.1.2.715

Synthesis of 2-(5-arylidene-4-oxo-3-arylthiazolydine-2)-N-phenylethanthiamides derivatives from malondithioamides

K. L. Obydennov, N. A. Golovko, Yu. Yu. Morzherin

Abstract

It is shown that thioacetamide are comfortable synthetic blocks for various heterocycles, including thiazole containing a double exocyclic bonds. This work describes the synthesis of (Z)-2-((Z)-5-arylidene-4-oxo-3-arylthiazolidin-2-ylidene)-N-arylethanethioamide 4 obtained from the Knoevenagel condensation of (Z)-2-(4-oxo-3-arylthiazolidin-2-ylidene)-N-arylylethanethioamide 2. The starting material 2 was synthesized by a Hantzsch reaction of N,N`-diarylmalondithioamides 1 and ethyl 2-chloroacetate. The structures of the obtained products were established by NMR and the structural features are discussed. Several 4-oxothiazolidin-2-ylidenes were studied by UV-visible spectroscopy technique

Keywords

thiomalonamides; chromophores; Oxidation reaction; knoevenagel condensation; thiazole

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DOI: https://doi.org/10.15826/chimtech.2014.1.2.715

Copyright (c) 2014 K. L. Obydennov, N. A. Golovko, Yu. Yu. Morzherin

This work is licensed under a Creative Commons Attribution 4.0 International License.

Chimica Techno Acta, 2014-2024
ISSN 2411-1414 (Online)
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